Effect of Streptococcus anginosus on biological response of tongue squamous cell carcinoma cells

Abstract Background Streptococcus anginosus ( S. ) was reported increased in oral squamous cell carcinoma (OSCC) tissue. The aim of this study to investigate the response cancer cells biological characteristics evoked by and its potential mechanisms. Methods growth curve concentration standard were determined, a series concentrations supernatant applied OSCC lines SCC15, then selected an optimal time CCK-8 assay. Then autophagic response, proliferative activity, cycle apoptosis, invasion migration abilities evaluated SCC15. Results results showed that when ratio culture medium 1:1 co-culture 16 h, inhibitory effect on SCC15 most obvious; Furthermore, upregulated autophagy activity thus significantly inhibiting proliferation, ability. Compared with control groups, G1 arrest, S G2/M phases decreased, percentage apoptotic relatively P < 0.05). Conclusion reduced promoted apoptosis; Moreover, may be one mechanisms process.